CD200R agonist overview

In development for atopic dermatitis.

Details

ARQ-234 is a fusion protein that serves as an agonist with high selectivity and potency for the CD200 receptor (CD200R).

  • As an immune regulatory receptor that is thought to be an important immunological checkpoint, CD200R has a pivotal role in the maintenance of immune tolerance
  • Activating receptors like CD200 are an example of checkpoint agonism that can amplify pathways that inhibit overactive immune cells and suppress unwanted immune responses
  • ARQ-234 binds to CD200R, restoring immune homeostasis by inducing inhibitory signaling on immune cells that regulate inflammation
Therapy

ARQ-234 is a CD200R agonist under investigation for the treatment of atopic dermatitis.

References

Arcutis Announces Acquisition of Ducentis BioTherapeutics Ltd. News release. Arcutis Biotherapeutics, Inc; September 7, 2022.

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